Piperidine Market Size, Share, Industry, Forecast and outlook (2024-2031)

Piperidine Market is Segmented By Type (99% Purity, 98% Purity), By Application (Pharmaceutical, Agrochemicals, Rubber, Others), By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2024-2031

Market Overview

The Report on the Global Piperidine Market is expected to reach at a CAGR of 6.10% during the forecast period 2024-2031.  Global Piperidine Market analyses the shares, size, recent trends, future market outlook, and competitive intelligence. Piperidine usage in to manufacture of piperidinyl lithium tetrasulfide is on the rise. Demand from the rubber industry and agrochemicals in ‘The Asia Pacific’ is spiking. The competitive rivalry intensifies with BASF SE, Koei Chemical Co. Ltd., and others active in the market. 

Piperidine is primarily used to manufacture piperidinyl lithium tetrasulfide, which is used as a rubber vulcanization accelerator. Piperidine is also used in the agrochemical, pharmaceutical, and food industries as a solvent and base for mepiquat chloride, dipyridamole, and minoxidil. Piperidine is a key saturated heterocyclic scaffold found in many of the most popular small molecule pharmaceuticals and natural alkaloids, with a wide range of biological activities. As a result, ongoing efforts have been made to develop simple methods for preparing piperidine derivatives. Piperidine is a colorless fuming liquid widely used in organic compound synthesis. Piperidine is clear with a peppery odor. It's much less dense than water but is miscible with it. Will float in the water. The flash point is 37°F. -15.8°F (-9°C) melting point 222.8°F (106°C) boiling point. Skin and eyes may be severely irritated by the compound and ingestion or inhalation may be toxic.

Market Scope and Summary

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Market Growth Dynamics and Trends

The market will be driven by the expanding pharmaceutical industry and the use of piperidine and its derivatives in producing APIs, and antimetastatic and antiproliferation drugs. However, the harmful effects of piperidine could be a major market restraint.

Growing pharmaceutical industry and application of piperidine and its derivatives in manufacturing APIs, antimetastatic and antiproliferation drugs

Coronary artery disease, diabetes, asthma, hepatitis, arthritis, and cancer have increased significantly in major regions worldwide over the last few decades. The aforementioned factor can be attributed to the world's growing geriatric population (by 2050, more than 20% of the global population is expected to be over 65 years old), lifestyles, and dietary changes caused by rapid urbanization. Due to the high prevalence and incidence of diseases, APIs are in greater demand for effective treatment. Leading market players are focusing on aligning their API product offerings toward treatments for chronic illnesses on the rise and expanding their production facilities to increase production capacity for APIs specific to managing different diseases.

Piperidine derivatives are a significant and diverse class of nitrogen-containing heterocyclic compounds. Piperidine moiety compounds exhibit a wide range of biological activities. Piperidine is a critical compound used in the manufacture of many drugs. They are commonly found in analgesic, anticancer, antimicrobial, anti-inflammatory, and antipsychotic medications. The piperidine and pyridine complexes are two of the most common heterocyclic fragments in FDA-approved drugs. Piperidine and its derivatives are commonly used in synthesizing active pharmaceutical ingredients (APIs) and fine chemicals. The product is a common organic compound or a structural element in many pharmaceutical intermediates.

Further, though over a hundred medically approved cancer chemotherapeutic medications exist, most anticancer drugs' toxicological data have limited their medicinal application as antiproliferative agents. Several piperidine alkaloids isolated from natural herbs, such as Piperine, Evodiamine, Matrine, Berberine, and Tetrandine, have been found to have antimetastatic and antiproliferation effects on various types of cancers in vitro and in vivo. Piperidine derivatives can also be used as anticancer agents. Vinblastine and raloxifene, for example, are chemotherapeutic agents with a piperidine group in their structure that are used as antimetastatic and antiproliferation drugs. Vinblastine, a plant alkaloid derived from Vinca Rosea, is used as an antineoplastic agent. Raloxifene is a selective estrogen receptor modulator of the second generation (SERM). It works as an estrogen blocker to reduce the risk of intrusive breast carcinoma in postmenopausal women. Thus, the market will be driven by the expanding pharmaceutical industry and the use of piperidine and its derivatives in producing APIs, antimetastatic, and antiproliferation drugs.

Harmful effects of piperidine

Piperidine is a highly toxic and flammable compound. When inhaled piperidine, it causes nasal and throat irritation, coughing, and wheezing. At normal room temperatures, piperidine emits explosive vapor concentrations. When heated, it transmits highly toxic nitrogen oxide fumes that can harm the human respiratory tract and make people more susceptible to respiratory illnesses and asthma. Chronic lung disease can be caused by long-term exposure to elevated nitrogen dioxide concentrations. Piperidine is a skin and mucous membrane irritant. After only a few minutes of exposure, it can cause lasting damage. Third-degree burns are established after only three minutes of skin contact in an unintentional case of piperidine skin exposure.

Long-term piperidine exposure can harm the respiratory tract, liver, gastrointestinal tract, and kidney. To avoid direct contact with piperidine, personnel using it is advised to wear a protective body suit, gloves, and eye goggles. Since the corrosive effects of piperidine increase the manufacturing, storage, and safety-related investments and draw regulatory bodies' attention, which again increases manufacturing costs to achieve certain regulatory standards, the harmful effects of piperidine are considered a major market restraint.

COVID-19 Impact on Piperidine Market

The pandemic COVID-19, like any other market, hurt the global piperidine market during its initial waves. The following are the key drivers of the market's steady decline during the pandemic:

• Because the production of piperidine has been disrupted, industrial-scale synthesis of piperidine requires massive machinery, large-scale industrial reagents, and skilled workers. During the pandemic, industry lockdowns and social distancing requirements severely hampered production.

• The global lockdown imposed by the COVID-19 pandemic hampered both the supply of raw materials necessary to manufacture piperidine and the supply of finished products. As a result, the demand-supply dynamics in the piperidine market were severely impacted.

• Lockdowns and a lack of raw materials in end-user industries reduced overall activity in these application sectors, lowering the demand for piperidine as raw material. However, the global piperidine market has the potential to grow tremendously, accelerated by the growth prospects shown by the pharmaceutical, agrochemical, and rubber industries.

Segmentation Analysis

The global piperidine market is classified based on type, application, and region.

Rising applications of 98% pure piperidine in the rubber industry and agrochemicals

Piperidine, with a purity of 98 percent, is primarily used in rubber production, herbicides and pesticides organic synthesis, and other applications. Piperidine is a component of finished active ingredients in agrochemicals or used as a base, solvent, catalyst, or other processing aid during manufacturing. The respective product is a critical component in producing the active ingredient mepiquat, a plant development regulator only used on cotton. Piperidine is primarily used in the production of elastomers. Organic vulcanizing accelerators based on piperidine, as opposed to inorganic vulcanizing accelerators, can be easily dissolved into the rubber compound. Piperidine produces valuable catalysts such as p-Phenylenediamine (PPD) and pentamethylene thiuram tetra sulfate (DPTS), ultra-accelerators, and vulcanizing agents.

Geographical Shares

Increasing construction activities and the need for sustainable polymers in the respective sector

The Asia-Pacific piperidine market was worth US$ YY million in 2022 and is expected to grow at a CAGR of YY percent over the forecast period, reaching US$ YY million by 2030. Piperidine is expected to be in high demand in the region's emerging economies due to the expansion of the pharmaceutical and agricultural sectors due to rapid economic development and government economic development initiatives. Furthermore, these countries' growing populations represent a sizable customer base.

Additionally, due to the low price, easy availability of raw materials, accessibility to transportation routes, and cheap labor, the region is a manufacturing hub of piperidine. Several manufacturers are further entering or expanding their regional presence by building manufacturing facilities. For instance, Avantor Inc. announced plans to integrate its existing distribution facility with new manufacturing operations in Singapore to establish a new manufacturing and distribution hub. Avantor will be able to better serve the fast-growing Asia Pacific biopharma market thanks to Singapore Manufacturing and Distribution Hub, which will allow for shorter lead times, improved supply chain security, and increased capacity in the region.

Companies and Competitive Landscape

In terms of global and local producer numbers and strengths, the global piperidine market is niche yet competitive due to the presence of major players such as BASF SE, Koei Chemical Co. Ltd., Vertellus, Toronto Research Chemicals, Merck KGaA, Jubilant Ingrevia Limited, Vasudha Pharma, Taj Pharmaceuticals Ltd, Avantor Inc, and Allchem Lifescience Pvt. Ltd. The market is fragmented and pivotal market stakeholders use market tactics such as mergers, acquisitions, product launches, contributions, and collaborations to gain a competitive advantage and recognition in their respective markets.

Vasudha Pharma

Overview: VASUDHA PHARMA CHEM LIMITED was established in 1994 as a public company under the companies in Hyderabad, Telangana, India. The company is involved in producing Active Pharmaceutical Ingredients (APIs) and Pharma Intermediates for the global market. Initially, the emphasis was on developing cost-effective processes for various intermediates related to piperidone and piperidine derivatives. By 2003-04, the company had developed world-class expertise and had grown to become the world's leading manufacturer of piperidone and piperidine derivatives. Following that, the company progressed from intermediates of piperidone and piperidine derivatives to APIs and later diversified into a large product portfolio of approximately 40+ APIs spread across several therapeutic areas.

Recognizing the importance of R&D in developing new products and processes, a completely separate R&D facility with 113 scientists was established in 2017. The company's gross sales have increased from US$ 0.25 million in FY 1997-98 to US$ 152 million in FY 2020-2021 due to the strength of its portfolio. Because of the importance placed on product quality, timely delivery, and competitive pricing, the proportion of export sales to gross sales is typically around 40%.

Product Portfolio:

• Piperidine Derivatives Drugs: Piperidine derivatives are one of the most basic heterocyclic systems and can be found in nature as a component of a variety of alkaloid chemical compounds. Piperidine derivatives, both natural and synthetic, exhibit a wide range of biological and pharmacological properties.

The chemical structural conformation of piperidine derivatives has been the subject of one of the most heated debates in structural organic chemistry in recent years. The conformational behavior of several piperidine-related compounds has been clarified due to the combined use of several advanced spectroscopic techniques. Vasudha Pharma manufactures piperidine derivatives such as N-Methyl and N-Benzyl piperidone. The products are extremely useful API intermediates and versatile in organic synthesis.

Key Development:

• On August 05, 2021, Vasudha Pharma Chem Limited's (VPCL) Long-Term Issuer Rating was confirmed at 'IND A+' by India Ratings and Research. VPCL has over two decades of experience producing active pharmaceutical ingredients (APIs) and pharma intermediates, as well as long-standing relationships with key customers. A significant portion of its sales is attributed to large domestic and multinational pharmaceutical companies with which VPCL has long-standing relationships, primarily for its key molecules. Over the last five years, the company has seen a consistent demand for these molecules, which it expects to continue in the medium term. All of the aforementioned factors, as well as several others, contribute to the company's above-mentioned success.