NGS Sample Preparation Market Size, Share, Industry, Forecast and outlook (2024-2031)

NGS Sample Preparation Market is Segmented By Product Type(Instruments and Kits, Reagents, Consumables), By Application(Disease Diagnostics, Drug Discovery, Agricultural and Animal Research, Others), By Technology (Sequencing by Synthesis (SBS), Ion Semiconductor Sequencing, Single-molecule Real-time (SMRT) Sequencing, Nanopore Sequencing, Others), By End-user (Hospitals & Clinics, Biotechnology & Pharmaceutical Companies, Contract research organization, Others) and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2024-2031

NGS Sample Preparation Market Overview

NGS Sample Preparation Market is Expected to reach at a CAGR of 19% during the forecast period (2024-2031). Preparing DNA for Next Generation Sequencing is known as sample preparation (NGS). DNA extraction, amplification, library construction, purification, and quality control are steps in the NGS sample preparation process. Various applications, such as forensic genomics, genetic genealogy, and DNA analysis, benefit from NGS kits and sample preparation equipment.

NGS Sample Preparation Market Scope

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NGS Sample Preparation Market Dynamics

Emerging technologies empowering next-generation sequencing (NGS) of DNA are expected to drive market growth.

NGS technology is substantially faster and less expensive than the Sanger sequencing technique, resulting in a higher sequencing yield. Short-read sequencing techniques, including synthesis sequencing, ion semiconductor sequencing, and nano ball sequencing, have significantly improved these results. This encouraged the use of next-generation sequencing (NGS) technology to reveal the complex biological settings around disease mechanisms. Their application for genetic diagnosis is currently attracting a lot of interest. For instance, Next-generation sequencing provides an effective way to study and identify new coronavirus strains and other pathogens. The technology is used to track and explore the novel coronavirus viral mutations. This work has helped the creation of multiple vaccines now being administered worldwide. It is critical to create new vaccines against new dangerous viral strains. The results will also be used to prevent future pandemics. In addition, the technology is allowing scientists and researchers to identify the underlying factors in individuals that contribute to their immune response to COVID-19. Thus, the market is expected to drive in the forecast period from the above statements.

Challenges associated with NGS Sample preparation are expected to hamper the market growth.

A small number of cells – or even a single cell – yields many samples. These do not produce enough genetic material on their own and are subjected to PCR. However, this amplification stage has the potential to introduce bias into the sample. When there are several copies of the same DNA fragment, this is known as PCR duplication. If too many PCR duplicates, the experiment's sequencing coverage will be inconsistent.

Moreover, During sample preparation, inefficient library construction is a concern; sample contamination is an inherent problem because separate libraries are usually prepared in parallel and Lab equipment. The need for trained personnel and reagent costs all contribute to the high costs of library production. Thus, the market is expected to get hampered in the forecast period from the above statements.

COVID-19 Impact Analysis On NGS Sample Preparation Market

The COVID-19 pandemic had a positive impact on the market. There are no specific antiviral agents available for its treatment. Pathogen genome sequencing has emerged as a tool to aid in studying disease outbreak molecular epidemiology, complementing and in some cases replacing more established techniques. For instance, sequencing has been used to help researchers better understand the epidemiology of Ebola virus disease, Zika virus, and Lassa fever. Today, the sequencing of the new coronavirus SARS-CoV-2 assists current vaccine development efforts. It adds to understanding the origins and progression of the ongoing COVID-19 pandemic.

Moreover, it gives the highest resolution information regarding pathogen genomes, allowing complete nucleotide sequences to be read. With the discovery of novel genomic variation at scale, next-generation sequencing has significant utility as a tool in infectious disease management. Therefore, it has increased the demand for NGS. Thus, it is expected to boost the NGS sample preparation market in the forecast period.   

NGS Sample Preparation Market Segment Analysis

Disease Diagnostics segment is expected to hold the largest market share in NGS sample preparation market

The disease diagnostics segment is expected to dominate in 2020. Many malignancies now have a growing number of potentially critical target mutations because of personalized medicine research. Next-generation sequencing (NGS) is a newer strategy that allows clinicians to test many cancer genes simultaneously. Material from a patient's tumor that has been biopsied or surgically excised can be used for next-generation sequencing. In some situations, it may be possible to screen a patient's blood sample for modest amounts of tumor DNA released by the malignancy. For instance, it provides the chance to test many genes simultaneously, potentially saving time, money, and tissue if many markers are needed. It can provide results not only for the mutations specifically needed but also can identify new markers that may offer additional treatment options, and a broader collection of markers may help researchers identify patterns of patient responses that may accelerate research.

Moreover, Detecting viruses, fungi, bacteria, and other pathogens requires diagnostic equipment. With the rising prevalence of COVID 19, there is a pressing need for diagnostic technologies that may be employed at reduced prices and produce better results. NGS can provide information on how to track down various virus transmission channels around the world to avoid the spread of new strains and discover viral alterations that can affect the detection process and vaccination potency. Thus, the market segment is expected to hold the largest market share in the forecast period from the above statements.

NGS Sample Preparation Market Geographical Analysis

North America region holds the largest market share in the global NGS sample preparation market

In 2020, North America accounted for the highest revenue share. The increasing prevalence of cancer, rising cases of infectious diseases, favorable government and private sector initiatives for the development and adoption of NGS technologies, adoption of NGS diagnostics, NGS-based research and clinical applications, rising awareness of NGS services and the presence of leading NGS service providers in the region are some of the factors due to which the market is expected to boost in the forecast period. For instance, in 2020, there will be an estimated 1.8 million new cancer cases diagnosed and 606,520 cancer deaths in the United States. Moreover, with the severe impact of the COVID 19 pandemic in this region, the next-generation sequencing market is gaining traction since it has a large market in clinical diagnostic tests. The novel COVID 19 variations appear to spread more quickly, perhaps increasing the pace of COVID 19 propagation.

Additionally, Illumina Inc. introduced Enancio technology in July 2020 to help minimize the expenses of genetic data storage and transport associated with big data. Lossless genome compression using DRAGEN ORA (previously Enancio's Lena) is available on-instrument with the NextSeq 1000/2000 Sequencing System and on the DRAGEN server v3.8. Therefore, it has increased the adoption of NGS technology by non-government and government agencies and support from the federal government and commercial players. Thus, the North American region is expected to hold the largest market share in the forecast period from the above statements.

NGS Sample Preparation Market Competitive Landscape

Major key players in the NGS sample preparation market are Illumina, Inc., Agilent Technologies, Inc., Thermo Fisher Scientific Inc. PerkinElmer, Inc., F.Hoffmann-La Roche AG, QIAGEN N.V., Twist Bioscience, Beckman Coulter, Tecan Trading AG and Pacific Biosciences of California, Inc.  

Thermo Fisher Scientific Inc.:

Overview:

Thermo Fisher Scientific is an American company incorporated in 1956 and is based in Waltham, Massachusetts. The company offers life sciences solutions, analytical instruments, specialty diagnostics, and laboratory products and services worldwide. Moreover, the global team has more than 90,000 colleagues who deliver an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon.

­Product Portfolio:

Ion GeneStudio S5 Systems: The Ion GeneStudio S5 systems are designed to enable a broad range of targeted next-generation sequencing (NGS) applications with speed and scalability. Five Ion S5 chips enable a sequencing throughput range of 2M to 130M reads per run.