Nerve Repair Biomaterials Market Size, Share, Industry, Forecast and outlook (2024-2031)

Global Nerve Repair Biomaterials Market is segmented By Product type (Nerve Conduit, Nerve Wrap, Nerve Graft, Others), By Application (Direct Nerve Repair, Nerve Grafting), By End-User (Hospitals and Clinics, Ambulatory Surgery Centers, Others), By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2024-2031

Nerve Repair Biomaterials Market Size

The global nerve repair biomaterials market size was valued US$ XX billion in 2022 and is estimated to reach US$ XX billion by 2031, growing at a CAGR of XX % during the forecast period (2024-2031).

Nerve damage is caused by injuries such as cuts, stretching or too much pressure. These injuries can result in mechanical, ischemic, thermal or chemical damages to the nerves. For the reconstruction of damaged nerves, nerve repair biomaterials are used.

Nerve Repair Biomaterials Market Summary

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Nerve Repair Biomaterials Market Dynamics

Increasing geriatric population affected by neurological diseases expected to drive the market's growth.

An increase in older adults will be characterized by a rise in the number of patients affected by a neurological disease. The geriatric population is at a higher risk of neurologic disorders such as stroke, neuropathy, Alzheimer’s disease, and Parkinson’s disease. Their higher susceptibility makes geriatrics a major segment of the overall patient pool. According to the WHO, the global population aged 60 years and above was 962 million in 2017 and expected to rise to 2.1 billion in 2050.  According to World Population Prospects (2019 Revision), by 2050, one in four persons residing in Europe and Northern America could be of 65 years or above. Hence, the growth of geriatric population segment has intensified the demand for nerve repair biomaterials for the treatment of neurological disorders.

Technological advancements in nerve conduits is expected to drive the market's growth.

Nerve conduits have been identified as one of the most promising treatments for peripheral nerve injuries. Existing nerve conduits must make trade-offs between mechanical strength and biocompatibility. With advancement in technology, a multi-nozzle additive-lathe 3D bioprinting technology is used to fabricate a bilayered nerve conduit. The materials of printing consist of gelatin methacrylate (GelMA)-based inner layer, which was cellularized with bone marrow mesenchymal stem cells and GelMA(ethylene glycol) diacrylate (PEGDA)-based outer layer. The high viability and extensive morphological spreading of BMSCs encapsulated in the inner layer was achieved by adjusting the degree of methacryloyl substitution and the concentration of GelMA. The addition of PEGDA obtained strong mechanical performance of the outer layer. The performance of the bilayered nerve conduits was assessed using in vitro culture of PC12 cells. The cell density of PC12 cells attached to cellularized bilayered nerve conduits was more than four times that on acellular bilayered nerve conduits. In addition, the increase rate of PC12 cells, which was attached to cellularized bilayered nerve conduits, was nine times higher than that of acellular bilayered nerve conduits. Therefore, these results demonstrate the additive-lathe 3D bioprinting of BMSCs embedded bilayered nerve conduits holds great potential in facilitating peripheral nerve repair.

Disadvantages associated with natural-based biomaterials for peripheral nerve injury Repair are expected to hamper the market's growth.

The degradation kinetics of the substrate must be compatible with the regeneration timing of the specific tissue for which it is used. Ideally, the scaffold should be combined into the surrounding tissue and gradually be replaced by the extracellular matrix and the cells to restore the functionality of the tissue. For instance, too fast degradation of the conduit can cause an inflammatory response inducing suboptimal nerve regeneration. Ideally, conduits should be fully resorbed when nerve repair is completed. Thus, the ideal degradation for a conduit should be faster at the proximal stump and gradually decreasing over distance with a slow degradation rate near the distal end. Thus, disadvantages associated with natural-based biomaterials for peripheral nerve injury repair are expected to hamper the market growth.

COVID-19 Impact Analysis

The COVID-19 pandemic has affected the healthcare systems and has a notable impact on the market. While many infectious disorders are unknown to most neurologists, COVID-19 is very different. It has impacted neurologists and other health care workers, not only in professional lives but also through the fear and panic within our own families, colleagues, patients and their families, and even in the wider public. The elderly with underlying chronic conditions are particularly at risk of severe disease or even death. Neurologists face various challenges in maintaining effective care for neurological disease patients without exposing them to the risk of infection.

COVID-19 has impacted the nerve repair biomaterials with reductions in the demand for biomaterials. They are used for peripheral nerve repair—nerve injuries from motor vehicle accidents, lacerations, penetrating trauma, stretching or crushing trauma and fractures, burns, and gunshot wounds. Due to the restrictions enforced to control the spread of COVID-19, vehicular traffic has reduced greatly in intensity; as a consequence, so has the number of road accidents.

Nerve Repair Biomaterials Market Segment Analysis

Nerve Conduit segment is expected to hold the largest market share in this market segment

The nerve conduit segment dominated the market for nerve repair biomaterials and accounted for the largest revenue share in 2020. The growth is attributed to increasing chronic compression injuries of nerves, increased cellular therapies, and conduits with various natural materials expected to boost the market in the forecast period. A nerve guidance conduit is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve injuries. Some of the materials used to make biologic tubes include blood vessels and skeletal muscles, while nonabsorbable and bioabsorbable synthetic tubes have been made from silicone and polyglycolide respectively.

Direct Nerve Repair segment is expected to hold the largest share in the market

The direct nerve repair segment dominated the market for nerve repair biomaterials and accounted for the largest revenue share in 2020. This can be attributed to the increasing incidence of neurological disorders across the globe. For instnace, as per the Alzheimer's Association (2020 estimates), the number of people above 65 years of age suffering from Alzheimer’s could reach 13.8 million by 2050 from 5.8 million in 2020. Also, as per the Parkinson’s Foundation estimated, disease incidence rises with age; only 4% of total cases are diagnosed before 50 years of age. In 2018, there were 145,519 people affected by the disease in UK. This is expected to cross 168,000 by 2025.

Direct nerve repair yields the best results, and nerve autografts remain the gold standard treatment for nerve gaps. Conduits have a limited role in small gaps <3 cm for sensory nerves, but this may expand in the future with improvements in conduit design.

Nerve Repair Biomaterials Market Geographical Share

North America region holds the largest market share in the global nerve repair biomaterials market.

North America held the largest market share in the nerve repair biomaterials market in 2020 and expected to dominate over the forecast period. The growth is attributed to the rising incidences of peripheral nerve injuries, the prevalence of neurological disorders, and proper repayment guidelines. There is a large and increasing burden of noncommunicable neurological disorders in the US, with up to a 5-fold variation in the burden of and trends in particular neurological disorders across the US states. the sophisticated healthcare infrastructure in countries such as Canada and the U.S., and the presence of a considerably large CNS disorder patient base are some drivers anticipated to fuel demand in the region. According to the Alzheimer’s Association, 1 in 10 Americans over the age of 65 has Alzheimer’s. More than 5 million Americans are living with Alzheimer’s and by 2050, it’s estimated there will be as many as 16 million Americans living with Alzheimer’s.

Nerve Repair Biomaterials Market Companies and Competitive Landscape

The nerve repair biomaterials market is moderately competitive with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Synovis Micro Companies Alliance, Inc., Integra LifeSciences, Checkpoint Surgical Inc, Collagen Matrix, Inc., Polyganics, Stryker, AxoGen, Inc., Polyganics, Abbott and Boston Scientific Corporation . The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the nerve repair biomaterials market globally.

Nerve Repair Biomaterials Market Key Companies to Watch

Axogen Inc.:

Overview:

Axogen, based in Alachua, Florida, is a developer of surgical solutions, including human tissue grafts. Its products are designed to remedy peripheral nerve damage and use cell graft technology AVANCE to mimic a human nerve. Moreover, the company also creates nerve connectors and soft tissue membranes, reports sensory and movement recovery in 87 percent of patients with peripheral nerve injuries. As of 2019, AxoGen was the only commercially available allograft approved by the Food and Drug Administration (FDA) for clinical use

Product Portfolio:

AxoGen, Inc. is into the continuous offering of nerve connectors and soft tissue membranes and human tissue grafts. The company offers Avance nerve graft and others.

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