Global In Vitro Toxicity Testing Market is segmented By Product & Service (Consumables, Equipment, Assay, Software, Services), By Toxicity Endpoint & Test (Genotoxicity Testing, Skin Irritation, Corrosion, & Sensitization Testing, Cytotoxicity Testing, Ocular Toxicity Testing, Organ Toxicity Testing, Others), By Technology (Toxicogenomics, Cell Culture Technologies, High-Throughput Technologies), By Industry (Pharmaceuticals & Biopharmaceuticals, Cosmetics & Household Products, Food, Chemicals), and By Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) – Share, Size, Outlook, and Opportunity Analysis, 2024-2031
Report Overview
Global In Vitro Toxicity Testing Market reached US$ XX million in 2023 and is expected to reach US$ XX million by 2031, growing at a CAGR of XX% during the forecast period 2024-2031.
In vitro toxicity testing is a scientific way of studying and establishing the impact of toxic substances on cells or tissues that are grown in a laboratory, excluding the pathogen but under very limited laboratory conditions. This procedure is a replacement for in vivo studies, which are procedures that involve baseline testing on live subjects; animals, or humans. In vitro toxicity assessment is a scientific process that aims at estimating the toxic effects of substances on cells or tissues cultured in a controlled laboratory environment not possibly on any living organism. It is a substitution for in vivo tests which are tests that involve living organisms ranging from animals to human beings.
The application of affordable yet effective tests can help the speed at which products reach the market. Additionally, in vitro models give researchers an advantage in understanding the biological process involved in a toxic response sooner than if they were depending on the visual inspection of a live animal.
Market Summary
| Metrics | Details |
| CAGR | XX% |
| Market Size | 2022-2031 |
| Market Estimation Forecast Period | 2024-2031 |
| Revenue Units | Value (US$ Mn) |
| Segments Covered | Product, Technology, Method, Application and End-User |
| Regions Covered | North America, Europe, Asia-Pacific, South America, and Middle East & Africa |
| Largest Region | North America |
| Fastest Growing Region | Asia-Pacific |
| Report Insights Covered | Competitive Landscape Analysis, Company Profile Analysis, Market Size, Share, Growth, Demand, Recent Developments, Mergers and Acquisitions, New Product Launches, Growth Strategies, Revenue Analysis, Porter's Analysis, Pricing Analysis, Regulatory Analysis, Supply-Chain Analysis, and Other key Insights. |
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Market Dynamics: Drivers
Technological progress, regulatory backing, and moral considerations
A new ethics related to the use of animals in toxicity tests is happening, resulting in regulatory bodies calling for other forms of testing. Today, there is a series of laws, for example, the European Union’s REACH regulation, stimulating the usage of non-animal testing methods. The modern approaches in cell culture technology, HTS, and other closed digital testing systems have made these non-animal tests more accurate and reliable. With the growth of pharmaceutical and biotech industries and the requirement for new research and development, more non-animal tests are required to evaluate the safety of new substances.
Support from the public and understanding of the existence of non-animal testing methods are driving industries to adopt the methods. The rise in the rate of chronic diseases docs up the need to come up with new drugs and therefore the need for toxicity testing is also highlighted. According to the WHO it is evident that illness such as heart diseases, cancer, CKD, COPD, and diabetes are today the leading causes of death. These diseases have claimed more lives than before; responding to the annual survey, 18% said that they died from chronic diseases in the past years.
According to data by the CDC, chronic diseases currently affect 60 % of all adults and, 40% of these have at least two chronic diseases. The diagnosed prevalence of diabetes has increased over past decade by over 300 percent. The factors are as follows: These factors cumulatively act as drivers for the development of the in vitro toxicity testing market.
Restraints
Challenges technical restraints, lack of standardization, high initial costs, low possibility of determining the future effects, reluctance for change are the factors that are hindering the growth of the in-vitro toxicity testing market.
Market Segment Analysis
The in-vitro toxicity testing market is segmented based on product, technology, method, application, end-user, and region.
The cell culture technology accounted for approximately 65.3% of the invitro toxicity testing market share
This in-vitro toxicity testing market can be divided based on technology, product, method, application, end-user, and geographic region.
The cell culture technology had about 65% of the share in the entire biopharmaceutical bioprocessing. Currently available data indicates that in-vitro toxicity testing market share possession is at 3% only. The market of in vitro toxicity testing is segmented by the technology, the product, the technique, the application, the user type, and the geography. Approximately 65. The segment with cell culture technology is holding only 3% of the global market share.
Any cytotoxicity testing that involves the use of cell culture technology attempts to mimic in vitro conditions to assess the impact of several reagents on the cells. It helps preserve a controlled environment and also circumvents the use of animal bodies for experimentation which constitutes a magnanimous aspect of the 3Rs process; Replacement, Reduction, and Refinement.
Dependent on the call type, there are different kinds of cell cultures that scientists use for those purposes. The most frequent ones are primary cell cultures, immortalized cell lines, and 3D cell cultures. It is crucial to note that the National Institute of Health (NIH) has described organ-on-chip and stem cell-derived models as innovative technologies. The European Center for the Validation of Replacement Methods employs cytotoxicity such as MTT and LDH assay for the measurement of cell toxicity. Two cytogenetic methods, comet assay, and micronucleus assay are used for genotoxicity assessments.
Cell culture technique plays a very vital role in the in vitro toxicity testing industry. A press release on cell culture technology, posted on its official website, on September 7, 2023, stated the creation of a human in vitro nutrition platform. This platform is aimed at enhancing cell function and metabolism and at identifying cell’s nutritional demands.
Market Geographical Share
North America accounted for approximately 42.3% of the in-vitro toxicity testing market share
The North American area is projected to maintain the highest market dominance throughout the projected timeframe. This is due to technological progress, the dominance of key players in the area, an increase in chronic disease prevalence, heightened public awareness, and the expansion of contract research organizations in this part of North America.
In North America, there are industrial collaborations and partnerships with many pharmaceutical and life sciences companies. Additionally, the upfront costs for starting operations in this area are considerable, owing to the surplus of financial resources available compared to other global regions. Pro Clinical Life Sciences reports that over the past five years, there has been a 20% increase in the expansion of the pharmaceutical and life sciences sectors in North America.
According to an article posted by the scientific magazine Pharmafile, in recent times the bio-rad laboratories have decided to merge with a Dutch company Qiagen. Also in 3rd August 2023, biorad laboratories decided to acquire all the shares of Curiosity Diagnostics which is a Poland-based diagnostic company.
Market Segmentation
By Product
- Consumables
- Equipment
- Assay
- Software
- Others
By Technology
- Cell culture technology
- High throughput technology
- Molecular imaging technology
- OMICS Technology
By Method
- Insilico
- Biochemical assay
- Cellular assay
- Ex-vivo
By Application
- Dermal Toxicity
- Systemic toxicity
- Endocrine disruption
- Ocular toxicity
- Others
By End-User
- Pharmaceutical Industry
- Diagnostic centers
- Food industry
- Cosmetic industry
- Research institutes
- Others
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- U.K.
- France
- Spain
- Italy
- Rest of Europe
- South America
- Brazil
- Argentina
- Rest of South America
- Asia-Pacific
- China
- India
- Japan
- South Korea
- Rest of Asia-Pacific
- Middle East and Africa
Market Competitive Landscape
The major global players in the invitro toxicity testing market include Abbott Laboratories, Agilent Technologies, Bio-Rad Laboratories, Covance, Eurofins Scientific, GE Healthcare, Merck KGaA, Promega Corporation, Quest Diagnostics, and Thermo Fisher Scientific, among others.
Key Developments
- In March 2023, Agilent Technologies acquired e-MSion. Through this acquisition, Agilent will integrate the e-MSion ExD cell into its advanced workflows and analytical solutions.
- In December 2023, Eurofins Scientific expanded in India with the establishment of a fully equipped state-of-the-art laboratory campus in Genome Valley Hyderabad. The lab supports advanced procedures and technologies in the field of life sciences in areas like organic chemistry, analytical R&D, toxicology, in-vitro pharmacology, and formulation.
- In January 2023, Abbott announced that they have signed an agreement which permits to market Abbott’s mobile testing system ‘SoToxa. This testing solution is a handheld oral fluid that offers a precise detection of drugs.
Why Purchase the Report?
- To visualize the in-vitro toxicity testing market segmentation based on product, technology, method, application, end-user, and region, as well as understand key commercial assets and players.
- Identify commercial opportunities by analyzing trends and co-development.
- Excel data sheet with numerous data points of invitro toxicity testing market level with all segments.
- PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.
- Product mapping is available in Excel consisting of key products of all the major players.
The in-vitro toxicity testing market report would provide approximately 70 tables, 69 figures, and 181 Pages.
Target Audience 2024
- Manufacturers/ Buyers
- Industry Investors/Investment Bankers
- Research Professionals
- Emerging Companies
