Market Overview
The Global Fluorescent in Situ Hybridization (FISH) Probe Market is Expected to reach at a CAGR of 8.9% during the forecast period (2024-2031).
Fluorescent in situ hybridization (FISH) is a molecular cytogenetic approach for visualizing and identifying an individual's genetic components using fluorescent probes. These probes are molecules that absorb a specific wavelength of light and then emit light when they bind to a specific DNA/RNA sequence. They're utilized to find structural and numerical chromosome abnormalities, evaluate treatment effects, and diagnose rare genetic illnesses.
Source: DataM Intelligence Analysis (2023)
Market Dynamics
Advancement in fluorescent in Situ Hybridization (FISH) probe is expected to drive market growth.
Detecting and image RNA at the single-cell level is critical for basic research and clinical diagnosis. Current RNA analysis techniques, such as fluorescence in situ hybridization (FISH), are time-consuming, sophisticated, and costly. Amplified FISH (AmpliFISH) uses small, ultrabright dye-loaded polymeric nanoparticles (NPs) functionalized with DNA to make RNA imaging easier and faster. Moreover, correct DNA-NP polymer matrix selection reduced nonspecific intracellular interactions. Using a simple 1 h staining approach, optimized DNA-NPs enabled sequence-specific imaging of various mRNA targets (survivin, actin, and polyA tails). These NPs enabled multiplexed detection of three mRNA targets simultaneously, showing distinctive mRNA expression profiles in three cancer cell lines.
Additionally, AmpliFISH was found to be semiquantitative, and it is found to correlate with RT-qPCR. AmpliFISH delivers an 8–200-fold greater signal (depending on the NP color) than the commercial locked nucleic acid (LNA)-based FISH technique and takes only three processes vs. 20 steps and a lot shorter time. As a result of the coupling of bright fluorescent polymeric NPs and FISH, a quick and sensitive single-cell transcriptomic analysis approach for RNA research and clinical diagnostics has been developed.
Restraint:
The High cost of fish probes, the presence of stringent regulatory approvals of products, lack of skilled professionals to interact with the technology and alternatives to FISH panels are some of the factors that the market is expected to hamper the market growth. For instance, Virtual karyotyping is a minimal, clinically available alternative to FISH panels, which use thousands to millions of probes on a single array to detect genome-wide copy number changes.
Industry Analysis
Porter’s Five Forces:
COVID-19 Impact Analysis
The COVID-19 pandemic had a positive impact on the market. A single linear RNA segment of the positive-sense single-stranded RNA virus acts as a template for transcription and replication, producing positive and negative-stranded viral RNA (vRNA) in infected cells. Tools to visualize viral RNA directly in infected cells are critical to analyzing its replication cycle, screening for therapeutic molecules or studying infections in human tissue. Tools to visualize viral RNA directly in infected cells are critical to analyzing its replication cycle, screening for therapeutic molecules, or studying human tissue infections. The design, validation and initial application of fluorescence in situ hybridization (FISH) probes visualize positive or negative RNA of SARS-CoV-2 (CoronaFISH).
Moreover, In RNA-FISH, single RNA molecules are typically targeted with 10–50 fluorescently labeled probes consisting of short (20-30 nucleotides), custom synthesized oligonucleotides with bioinformatically designed sequences. Individual RNAs are subsequently visible as bright, diffraction-limited spots under a microscope. It can be detected with appropriate image analysis methods. Therefore, it increases the demand for fluorescent in situ hybridization (FISH) probes. Thus, it is expected to boost the fluorescent in situ hybridization (FISH) probe market in the forecast period.
Segment Analysis
RNA segment is expected to hold the largest market share in luorescent in situ hybridization (FISH) probe market
The RNA segment is expected to dominate in 2020. RNA probes are preferred because RNA-RNA hybrids are more stable than DNA-RNA hybrids, allowing for a more efficient labeling reaction. RNA probes are commonly used in cancer research and can assist in distinguishing between cancer subtypes. Moreover, because of their high sensitivity, good interference tolerance, fast detection, and adaptability, nucleic acid probe-based fluorescence sensing and imaging have made significant advances in a range of cancer management strategies. Here, sophisticated fluorophores are used to label nucleic acid probe-based fluorescence sensing and imaging, which are critical for detecting aberrant nucleic acids and other cancer-relevant molecules quickly and sensitively, allowing for early cancer diagnosis and tailored treatment. For instance, miRNAs have become ideal and noninvasive cancer biomarkers. To accomplish better and faster miRNA imaging, Au nanoparticles (AuNPs)/double-specific nuclease (DSN), AgNC-generating MBs (AgNC-MBs), reduced graphene oxide (rGO), FAM, OTP-ZnCl2, Hsd, and NBE-modified fluorescent probes are applied for fabricating imaging platforms and measuring mutant-type targets in the diagnosis of various cancers.
Additionally, INFORM HER 2/ NEU probe, produced by Ventana Medical Systems, PATHYVISION HER- 2 by Abbott Molecular, and HER2 FISH PharmDx are fluorescence hybridization kits for companion diagnostic usage. Thus, the market segment is expected to hold the largest market share in the forecast period from the above statements.
Source: DataM Intelligence Analysis (2021)
Geographical Analysis
North America region holds the largest market share in the global fluorescent in situ hybridization (FISH) probe market
In 2020, North America accounted for the highest revenue share. The increasing prevalence of genetic disorders, rising cases of cancer, raising awareness among people with early diagnosis of developmental disabilities, increasing disposable income, increase in demand for early cancer detection capabilities and a focus on the development of personalized medicine and diagnostics tests and product approvals in the region are some of the factors due to which the market is expected to boost in the forecast period. For instance, Cystic fibrosis is a common genetic disease within the white population in the United States. The disease occurs in 1 in 2,500 to 3,500 white newborns. Cystic fibrosis is less common in other ethnic groups, affecting about 1 in 17,000 African Americans and 1 in 31,000 Asian Americans.
Moreover, Oxford Gene Technology received FDA (Food and Drug Administration) approval in 2019 for eight fish probes that will be used to identify acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) (MDS). Therefore, the above statements have increased the demand for fluorescent in situ hybridization (FISH) probes. Thus, the North American region is expected to hold the largest market share in the forecast period.
Source: DataM Intelligence Analysis (2021)
Competitive Landscape
Major key players in the fluorescent in Situ hybridization (FISH) probe market are ThermoFisher Scientific Inc., Agilent Technologies, Genemed Technologies Inc., MetaSystems Probes, CytoTest Inc., Creative Biolabs, Abbott Molecular Inc., Oxford Gene Technology IP Ltd., Sigma-Aldrich Solutions and Empire Genomics, Inc.
Thermo Fisher Scientific Inc.:
Overview:
Thermo Fisher Scientific is an American company incorporated in 1956 and is based in Waltham, Massachusetts. The company offers life sciences solutions, analytical instruments, specialty diagnostics, and laboratory products and services worldwide. Moreover, the global team has more than 90,000 colleagues who deliver an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon.
Product Portfolio:
Fluorescence In Situ Hybridization (FISH): Multiplex fluorescence in situ hybridization (FISH) allows to test many targets in a single specimen and see colocalized results. This method, which employs spectrally different fluorophore labels for each hybridization probe, allows resolving various genetic elements or gene expression patterns using a multicolor visual display.
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- Visualize the composition of the fluorescent in situ hybridization (FISH) probe market segmentation by probe type, technology, type, application, end user and region highlighting the key commercial assets and players.
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